Nine Formulas.
One System.
The Oralopticeutical™ category — precision bioactive oral science built on three peer-reviewed peptide bioregulators. Two series. Professional and consumer. No prescription required.
Opti Series
Professional Clinical Line — 5 Products
OptiOral Home
Daily Consumer Line — 4 Products
The Science Inside Every Product
Three peer-reviewed peptide bioregulators. Every formula.
GHK (Gly-His-Lys)
Declines more than 60% between age 20 and 60. Published to influence more than 4,000 human genes including collagen synthesis, ECM remodeling, angiogenesis, and antimicrobial pathways.
Pickart & Margolina, Int J Mol Sci 2018
Ac-AEDG-NH₂
Studied directly in human gingival mesenchymal stem cells (hGMSCs): p16 reduced 1.92×, p21 reduced 2.44× (p<0.01). Activates telomerase. Epigenetic chromatin remodeling in oral stem cells.
Khavinson et al., Molecules 2020
Ac-KE-NH₂
Modulates NFκB — the master transcription factor driving IL-1β, TNF-α, and RANKL in periodontal tissue. T-cell differentiation and NK cell immune regulation.
Khavinson et al., Front Genet 2019
OptiOral Professional
Professional clinical products for chairside use and clinician dispensing. Higher concentration, targeted delivery formats. For periodontists, implant surgeons, and general practitioners managing periodontal disease and implant outcomes.
OptiOral Rinse
Bioregulator Oral Rinse
The first oral rinse in the Oralopticeutical™ category. Formulated with three peer-reviewed peptide bioregulators in a mucoadhesive vehicle. Hold 60–90 seconds. Dispensed by clinician as an adjunct to professional periodontal care.
Format
Aqueous rinse · pH 5.8 · 15–20 mL per use · Amber glass bottle with dosing cap
Active Ingredients
Human gingival stem cell research — p16 reduced 1.92×, p21 reduced 2.44× (p<0.01)
NFκB modulation · T-cell and NK cell immune regulation
Naturally present in human saliva · influences >4,000 human genes · collagen synthesis
Formulated with ingredients selected on the basis of peer-reviewed published literature. No drug claims are made or intended.
OptiOral Socket
Extraction Site Collagen Carrier
Resorbable collagen sponge pre-loaded with a triple-peptide bioregulator blend. Placed at the time of extraction prior to socket closure. Resorbs over 10–14 days with progressive peptide release into the healing wound bed.
Format
Sterile absorbable collagen sponge · 1 cm × 2 cm × 0.5 cm · Individually foil-packaged · Single use
Active Ingredients
Stem cell activation at socket margin
Local innate immune modulation
Wound closure acceleration · ECM accumulation · fibroblast activation
Formulated with ingredients selected on the basis of peer-reviewed published literature. No drug claims are made or intended.
OptiOral Surge
Surgical Site Thermosensitive Gel
Thermosensitive hydrogel applied at flap closure. Liquid at room temperature, gels on contact with tissue at 37°C. Conforms to the wound surface without suture. Provides sustained peptide release over 4–24 hours during the critical early wound response window.
Format
1.5 mL sterile pre-filled syringe · Refrigerated storage 4–8°C · Blunt-tip applicator · Single use
Active Ingredients
Stem cell activation at graft interface
Fibroblast replicative vitality · collagen synthesis · ECM organization
Formulated with ingredients selected on the basis of peer-reviewed published literature. No drug claims are made or intended.
OptiOral Seal
Peri-Implant Sulcular Gel
Precision sulcular delivery gel applied to the peri-implant sulcus via micro-syringe following mechanical decontamination. Formulated around the two biological components of peri-implant disease that debridement alone does not address.
Format
0.5 mL sterile pre-filled micro-syringe · 23-gauge blunt periodontal tip · Boxed in units of 10 · Single use
Active Ingredients
NFκB suppression · peri-implant immune environment
Soft tissue collar adaptation · collagen synthesis · antimicrobial
Formulated with ingredients selected on the basis of peer-reviewed published literature. No drug claims are made or intended.
OptiOral Root
Root Surface Conditioning Gel
Applied directly to the instrumented root surface prior to membrane placement. Formulated on the basis of published literature on peptide activity at conditioned root surfaces and in periodontal ligament stem cells. 60-second contact time prior to membrane placement.
Format
1.0 mL sterile pre-filled syringe · Blunt delivery tip · Semi-viscous gel pH 6.8 · Ambient storage · Single use
Active Ingredients
PDL stem cell anti-senescence · p16/p21 reduction in hPDLSCs
Root surface ECM conditioning · fibroblast activation · cell attachment support
Formulated with ingredients selected on the basis of peer-reviewed published literature. No drug claims are made or intended.
All OptiOral Care products are formulated with ingredients selected on the basis of peer-reviewed published scientific literature. Opti Series products are professional-use preparations for clinician administration or dispensing. OptiCare Oral Series products are dietary supplements under 21 U.S.C. §321(ff). No drug claims are made or intended. These products have not been evaluated by the U.S. Food and Drug Administration. Not intended to diagnose, treat, cure, or prevent any disease. Patent pending.
Daily protocol.
Compliance window.
The OptiOral Home line extends the Opti Series clinical protocol into the patient's daily routine. Same three peer-reviewed peptide bioregulators — GHK, Ac-AEDG-NH₂, and Ac-KE-NH₂ — in compliance-optimized formats. Practice-dispensed or direct subscription.
OptiOral Care Rinse
Daily Bioregulator RinseThe daily home-use counterpart to OptiOral Rinse — the same three peptide bioregulators in a compliance-optimized format for twice-daily use between professional visits. Practice-dispensed or direct subscription. Extends the professional protocol into every day.
Ac-AEDG-NH₂ 75 µg/mL · Ac-KE-NH₂ 40 µg/mL · GHK 200 µg/mL
Early Access →OptiOral Paste
Bioregulator ToothpasteThe first toothpaste formulated with peptide bioregulators. Combines GHK and Ac-KE-NH₂ with nano-hydroxyapatite for enamel support, delivering bioregulators to the gingival margin during the brushing window. No SLS. No artificial colors.
GHK 300 µg/g · Ac-KE-NH₂ 50 µg/g · nano-Hydroxyapatite 10% w/w
Early Access →OptiOral Strip
Dissolvable Sublingual FilmDissolvable sublingual film delivering Ac-AEDG-NH₂ and Ac-KE-NH₂ via rapid buccal mucosal absorption. Dissolves in 45–90 seconds. Designed for patients who prefer a targeted, fast-absorbing format over a rinse.
Ac-AEDG-NH₂ 100 µg/strip · Ac-KE-NH₂ 60 µg/strip
Early Access →OptiOral Mist
Highest-Bioavailability FormatSublingual spray delivering Ac-AEDG-NH₂ and GHK via the sublingual venous plexus — bypassing first-pass hepatic metabolism. Two actuations under the tongue, held 60 seconds. The highest-bioavailability format in the OptiOral Home line.
Ac-AEDG-NH₂ 500 µg/mL · GHK 1,000 µg/mL
Early Access →