Professional Rinse
The OptiOral Care SystemNine formulas.
Nine formulas.
Two series.
Every product formulated with GHK, Ac-AEDG-NH₂, and Ac-KE-NH₂ — three peer-reviewed peptide bioregulators with published evidence in human gingival and periodontal tissue.
Opti Series — Professional Clinical Line
Extraction Site
OptiSocket™ — Collagen Carrier · Surgical
Surgical Site
OptiSurge™ — Thermosensitive Hydrogel · Surgical
Peri-Implant
OptiSeal™ — Sulcular Gel · Implant Maintenance
Root Surface
OptiRoot™ — Conditioning Gel · GTR Adjunct
OptiCare Oral Series — Daily Consumer Line
Daily RinseOptiCare Oral Rinse™Daily Home Use · Twice Daily
ToothpasteOptiCare Oral Paste™Bioregulator Toothpaste · No SLS
Sublingual FilmOptiCare Oral Strip™Dissolvable Film · 60 Seconds
Sublingual SprayOptiCare Oral Mist™Highest Bioavailability Format
The BioregulatorsShort-chain peptides.
Short-chain peptides.
Long-studied biology.
Every OptiOral Care formula is built around three bioregulator peptides with published evidence of direct activity in human gingival and periodontal tissue. We list the compounds. The research speaks for itself.
· GHK
The Tissue Repair Signal
A naturally occurring tripeptide present in human saliva and plasma. Levels decline from ~200 ng/mL at age 20 to ~80 ng/mL by age 60 — a greater than 60% reduction tracking directly with reduced healing capacity. Published gene array analysis demonstrates GHK modulates more than 4,000 human genes simultaneously. In a comparative human trial with biopsy confirmation, GHK produced collagen increases in 70% of subjects versus 50% for Vitamin C and 40% for retinoic acid.
Pickart & Margolina, Int J Mol Sci 2018 · Abdulghani et al., comparative collagen trial 1998
· Ac-AEDG-NH₂
The Stem Cell Activator
Novel dual-terminus modified analog of AEDG (Epitalon). Published 2020 study using human gingival mesenchymal stem cells (hGMSCs): p16 reduced 1.92-fold and p21 reduced 2.44-fold (p<0.01) — directly restoring proliferative capacity in gingival stem cells. Confirmed in human periodontal ligament stem cells (hPDLSCs). Activates telomerase via hTERT upregulation. Dual-terminus modification blocks salivary proteolysis.
Khavinson et al., Molecules 2020 (hGMSC, p<0.01) · Sinjari et al., Stem Cell Rev. Reps. 2020 (hPDLSC)
· Ac-KE-NH₂
The Immune Regulator
Novel dual-terminus modified analog of KE (Vilon). Directly modulates NFκB — the master transcription factor driving IL-1β, TNF-α, and RANKL in periodontal tissue. RANKL drives osteoclast activation and alveolar bone resorption. In a 6-year prospective human study of 266 subjects, the KE-class peptide produced a 4.1-fold reduction in mortality with normalization of immune indices — zero adverse events.
Khavinson & Morozov, Neuroendocrinol Lett 2003 (6-year human study, n=266) · Khavinson et al., Front Genet 2019
Delivery Science
Buccal Mucosal Absorption
The oral mucosa is a highly vascularized absorptive surface with direct access to the sublingual venous plexus. Short-chain peptides of 2–7 amino acids are absorbed at clinically relevant concentrations during a 60–90 second hold. Chitosan in OptiRegen™ and OptiCare Oral Rinse™ transiently opens epithelial tight junctions for paracellular transport into subepithelial tissue where gingival fibroblasts and stem cells reside.
Dual-Terminus Modification
Native peptide sequences are cleaved by salivary aminopeptidases within minutes of oral contact. The Ac-X-NH₂ analogs — Ac-AEDG-NH₂ and Ac-KE-NH₂ — bear N-terminal acetylation and C-terminal amidation, blocking both proteolytic attack points. This extends active compound half-life in the oral environment from minutes to hours — the key innovation enabling therapeutic tissue exposure from a non-injectable oral format.
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First production run.
OptiOral Care is entering its first professional distribution run. Place your order inquiry now to secure early access priority.